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In Vivo and In Vitro Characterization of Provodine, a Long Acting, Alcohol-Free Professional Antiseptic, Against Ebola Virus and Other Serious Viral, Bacterial and Fungal Pathogens

Background. Control of the spread of Ebola and other deadly pathogens is essential to the success of military and public health efforts wherever this virus or other Category A/B pathogens emerge. While many disinfectants may be available to control the spread of virus particles, there are no codified antiseptic products safe for use on skin and …

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Discovery of Novel Small Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1

A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and virion release. For HIV-1 infection, during entry, the virus triggers early actin activity through hijacking chemokine coreceptor signaling which activates a host dependency factor cofilin and its kinase, the LIM domain kinase (LIMK). Although knockdown of human LIMK1 with shRNA inhibits HIV infection, …

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