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In Vivo and In Vitro Characterization of Provodine, a Long Acting, Alcohol-Free Professional Antiseptic, Against Ebola Virus and Other Serious Viral, Bacterial and Fungal Pathogens

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Background. Control of the spread of Ebola and other deadly pathogens is essential to the success of military and public health efforts wherever this virus or other Category A/B pathogens emerge. While many disinfectants may be available to control the spread of virus particles, there are no codified antiseptic products safe for use on skin and …

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Discovery of Novel Small Molecule Inhibitors of LIM Domain Kinase for Inhibiting HIV-1

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A dynamic actin cytoskeleton is necessary for viral entry, intracellular migration, and virion release. For HIV-1 infection, during entry, the virus triggers early actin activity through hijacking chemokine coreceptor signaling which activates a host dependency factor cofilin and its kinase, the LIM domain kinase (LIMK). Although knockdown of human LIMK1 with shRNA inhibits HIV infection, …

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